Evaluation of the efficacy of usage of the drug arginine in complex therapy of generalized periodontitis by laser doppler's fluometry

Authors

  • Анатолій Васильович Борисенко
  • Олексій Сергійович Куваєв
  • Ганна Володимирівна Відерська

DOI:

https://doi.org/10.33295/1992-576X-2019-3-28

Keywords:

generalized periodontitis, pharmaceutical composition, arginine, Laser Doppler Flowmetry

Abstract

Urgency. Periodontal disease is the most common human diseases. The problem of rational treatment of generalized periodontitis is relevant. In the complex treatment of generalized periodontitis traditionally used different groups of drugs. Today attracts role of nitric oxide in the development of various pathologic processes. Important links of generalized periodontitis is oxidative stress, disturbance of metabolism of nitric oxide and haemomicrocirculation. All of this calls for the correction of these mechanisms of pathogenesis of generalized periodontitis in its complex treatment. For this purpose it is possible to apply medicinal composition of arginine, L-arginine as a source of nitric oxide. Laser Doppler Flowmetry was used to evaluate the treatment efficacy.
Aim. The determination of the effectiveness of the proposed pharmacological composition with arginine in the complex treatment of patients with generalized periodontitis, by assessing the state of blood flow in periodontal microvessels by Laser Doppler Flowmetry.
Materials and methods. Clinical studies performed on a group of 70 patients with generalized periodontitis. Patients were conducted a comprehensive examination of periodontal tissue before treatment and after treatment. To evaluate the clinical efficacy of treatment used Schiller-Pisarev test 1962), the index of PMA by C. Parma (1961), hygienic index by Green-Vermillion (1964), vacuum test by Kulazhenko (1961). Laser Doppler Flowmetry was used to evaluate the treatment efficacy.
Results. As a result of the study it was found that the inclusion of the proposed pharmaceutical composition in the complex therapy of patients with generalized periodontitis allows you to more effectively suppressed the dystrophic-inflammatory process in periodontal tissues. This confirms the decline of the PMA index, increase the time of hematoma formation during the vacuum tests on Kulazhenko, improving oral hygiene, and improvement of microcirculation parameters in periodontal tissues of patients.
Conclusions. Application of the proposed pharmaceutical composition increases the effectiveness of treatment of patients with generalized periodontitis, and improvement of microcirculation parameters in periodontal tissues of patients.
Key words: generalized periodontitis, pharmaceutical composition, arginine, Laser Doppler Flowmetry.

Author Biographies

Анатолій Васильович Борисенко

Борисенко Анатолій Васильович – д-р мед. наук, професор,
завідувач кафедри терапевтичної стоматології Національного медичного університету ім. О.О.Богомольця.
Тел.: +38 (050) 447-38-00. E-mail: anatoliyborysenko.nmu@gmail.com.

Олексій Сергійович Куваєв

Куваєв Олексій Сергійович – асистент кафедри терапевтичної стоматології
Національного медичного університету ім. О.О. Богомольця.
Тел.: +38 (067) 858-29-26. E-mail: doctordentist@ukr.net.

Ганна Володимирівна Відерська

Відерська Ганна Володимирівна – канд. мед. наук, асистент кафедри терапевтичної стоматології
Національного медичного університету ім. О.О. Богомольця. Тел.: +38 (067) 296-05-21.

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Published

2019-10-10

Issue

Section

PARADONTOLOGY