Morphological aspects of the implant-bone interface in the long postoperative periodafter implantation
DOI:
https://doi.org/10.33295/1992-576X-2019-5-75Keywords:
morphological aspects of the implant-bone interface, energy dispersive analysis, implantAbstract
Summary. Of the many constituent aspects of the success of implantation, osseointegration is perhaps the most important and in itself depends on several factors, including the biomedical characteristics of the implant, the ability to protect against adjacent tissue stress and the longevity of functioning after implantation. To date, there is an insufficient number of results of an objective assessment of the implant-bone interface in vivo in the long term functioning of the implant in humans.
Objective: to study the morphological aspects of the implant-bone interface in the long-term functioning of dental implants of various alloys.
Materials and methods. Due to the failure of the orthopedic design or due to the failure of the structural elements of the superstructure, if it is impossible to repair, the implants were removed, followed by augmentation to the area of the resulting defect. We studied dental implants from titanium alloy (Grade5) – 7.6 ± 1.5 years after installation (3 cases), zirconium (KTZ-125) – 5.7 ± 1.9 (4 cases), betta-titanium-zirconium alloy – 6.2 ± 2.6 years after installation (3 cases). After extraction, the implant bone interface was studied by scanning electron microscopy with energy dispersive analysis and histology with hematoxylin- eosin staining.
Results. Implant / bone interface status in remote structures of various compositions has shown the advantage of beta-titanium-zirconium alloy over Grade5 and KTZ 125. The number of observations does not allow to reveal a reliable dependence of the interface structure on different implant geometry, but a decrease in the number of bone microcracks and the absence of connective tissue may indicate the advantage of a rotation parabola.
Key words: morphological aspects of the implant-bone interface, energy dispersive analysis, implant.
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References
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response. Trends Biotechnol. 2016 Jun;34(6):470-482. DOI: 10.1016/j.tibtech.2016.03.009
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cell behaviors and tissue engineering. Chem Rev. 2017 Mar 8; 117(5): 4376–4421. DOI: 10.1021/
acs.chemrev.6b00654
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Biomaterials. 2003 Oct; 24(22): 3893–907. DOI: 10.1016/s0142-9612(03)00261-8
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295(5557): 1014–7. DOI: 10.1126/science.1067404
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nano-textured titanium surface with titania nanotubes on osteoblast functions. Biomaterials.
2010 Jul; 31(19): 5072-82. DOI: 10.1016/j.biomaterials.2010.03.014
39. Zhou R, Wei D, Cao J, Feng W, Cheng S, Du Q, et al. Synergistic effects of surface
chemistry and topologic structure from modified microarc oxidation coatings on ti implants for
improving osseointegration. ACS Appl. Mater. Inter. 7 (2015) Apr 8932–8941. DOI: 10.1021/
acsami.5b02226
40. Murphy WL, McDevitt TC, Engler AJ. Materials as stem cell regulators. Nat Mater.
2014 Jun; 13(6): 547–57. DOI: 10.1038/nmat3937
41. Stevens MM, George JH. Exploring and Engineering the Cell Surface Interface.
Science. 2005 Nov 18; 310(5751): 1135–8. DOI: 10.1126/science.1106587
42. Anderson JM, Rodriguez A, Chang DT. Foreign body reaction to biomaterials.
Semin Immunol. 2008 Apr; 20(2): 86–100. DOI: 10.1016/j.smim.2007.11.004
43. Jones JA, Chang DT, Meyerson H, Colton E, Kwon IK, Matsuda T, et al. Proteomic
analysis and quantification of cytokines and chemokines from biomaterial surface-adherent
macrophages and foreign body giant cells. J Biomed Mater Res A. 2007 Dec 1; 83(3): 585–96.
DOI: 10.1002/jbm.a.31221
44. Hench LL, Polak JM. Third-generation biomedical materials. Science. 2002 Feb 8;
295(5557): 1014–7. DOI: 10.1126/science.1067404
45. Jell G, Stevens MM. Gene activation by bioactive glasses. J Mater Sci Mater Med.
2006 Nov; 17(11): 997–1002. DOI: 10.1007/s10856-006-0435-9
46. Kriparamanan R, Aswath P, Zhou A, Tang L, Nguyen KT. Nanotopography: cellular
responses to nanostructured materials. J Nanosci Nanotechnol. 2006 Jul; 6(7):1 905–19.
DOI: 10.1166/jnn.2006.330
Eur Spine J. 2001 Oct;10(2):96-101.
DOI: 10.1007/s005860100282
2. Kurtz SM, Devine JN. PEEK biomaterials in trauma, orthopedic, and spinal
implants. Biomaterials. 2007 Nov; 28(32): 4845–69.
DOI: 10.1016/j.biomaterials.2007.07.013
3. Branemark PI. Osseointegration and its experimental background. J Prosthet
Dent. 1983 Sep;50(3):399–410. DOI: 10.1016/s0022-3913(83)80101-2
4. Szmukler-Moncler S, Salama H, Reingewirtz Y, Dubruille JH. Timing of loading and
effect of micromotion on bone-dental implant interface: review of experimental literature. J Biomed
Mater Res. 1998 Summer; 43(2): 192–203. DOI: 10.1002/(sici)1097-4636(199822)43:2
<192::aid-jbm14>3.0.co;2-k
5. Spears IR, Pfleiderer M, Schneider E, Hille E, Morlock MM. The effect of interfacial
parameters on cup-bone relative micromotions. A finite element investigation. J Biomech.
2001 Jan; 34(1): 113–20. DOI: 10.1016/s0021-9290(00)00112-3
6. Schenk RK, Buser D. Osseointegration: a reality. Periodontol 2000. 1998 Jun;17:
22–35.
7. Donath K. Vergleichende histologische Untersuchung verschiedener enossaler
Implantattypen. Z Zahnaerztl Implantol 1988;4:106–8.
8. Davies JE. Mechanisms of endosseous integration. Int J Prosthodont. 1998 Sep-
Oct; 11(5): 391–401.
9. Branemark PI. Osseointegration and its experimental background. J Prosthet
Dent. 1983 Sep;50(3):399–410. DOI: 10.1016/s0022-3913(83)80101-2
10. Aspenberg P, Goodman S, Toksvig-Larsen S, Ryd L, Albrektsson T. Intermittent
micromotion inhibits bone ingrowth. Titanium implants in rabbits. Acta Orthop Scand. 1992
Apr;63(2): 41–5. DOI: 10.3109/17453679209154809
11. Gondolph-Zink B. [Effect of hydroxyapatite layering on the osteo-integration of
weightbearing and non-weightbearing implants. Comparison to other microporous surfaces in
animal experiments]. Orthopade. 1998 Feb; 27(2): 96–104.
12. Brunski JB. In vivo bone response to biomechanical loading at the bone/dentalimplant
interface. Adv Dent Res. 1999 Jun; 13: 99–119. DOI: 10.1177/08959374990130012301
13. Chang YS, Gu HO, Kobayashi M, Oka M. Influence of various structure treatments
on histological fixation of titanium implants. J Arthroplasty. 1998 Oct; 3(7): 816–25.
DOI: 10.1016/s0883-5403(98)90037-7
14. D’Lima DD, Lemperle SM, Chen PC, Holmes RE, Colwell Jr CW. Bone response to
implant surface morphology. J Arthroplasty. 1998 Dec; 13(8): 928–34. DOI: 10.1016/s0883-
5403(98)90201-7
15. Li J, Liao H, Fartash B, Hermansson L, Johnsson T. Surface- dimpled commercially
pure titanium implant and bone ingrowth. Biomaterials. 1997 May; 18(9): 691–6. DOI: 10.1016/
S0142-9612(96)00185-8
16. Schwartz Z, Boyan BD. Underlying mechanisms at the bone- biomaterial interface.
J Cell Biochem. 1994 Nov; 56(3): 340–7. DOI: 10.1002/jcb.240560310
17. Kasemo B, Gold J. Implant surfaces and interface processes. Adv Dent Res. 1999
Jun; 13: 8–20. DOI: 10.1177/08959374990130011901
18. Thomas KA, Kay JF, Cook SD, Jarcho M. The effect of surface macrotexture and
hydroxylapatite coating on the mechanical strengths and histologic profiles of titanium implant
materials. J Biomed Mater Res. 1987 Dec; 21(12): 1395–414. DOI: 10.1002/jbm.820211205
19. Buser D, Schenk RK, Steinemann S, Fiorellini JP, Fox CH, Stich H. Influence of
surface characteristics on bone integration of titanium implants. A histomorphometric study in
miniature pigs. J Biomed Mater Res. 1991 Jul; 25(7): 889–902. DOI: 10.1002/jbm.820250708
20. Thomas KA, Cook SD. Relationship between surface character- istics and the
degree of bone–implant integration. J Biomed Mater Res. 1992 Jun; 26(6): 831–3. DOI:
10.1002/jbm.820260612
21. Feighan JE, Goldberg VM, Davy D, Parr JA, Stevenson S. The influence of surfaceblasting
on the incorporation of titanium- alloy implants in a rabbit intramedullary model. J Bone
Joint Surg Am. 1995 Sep; 77(9): 1380–95. DOI: 10.2106/00004623-199509000-00015
22. Cooper LF. A role for surface topography in creating and maintaining bone at titanium
endosseous implants. J Prosthet Dent. 2000 Nov; 84(5): 522–34. DOI: 10.1067/
mpr.2000.111966
23. Hulbert SF, Cooke FW, Klawitter JJ, Leonard RB, Sauer BW, Moyle DD et al.
Attachment of prostheses to the musculoskeletal system by tissue ingrowth and mechanical
interlocking. J Biomed Mater Res. 1973; 7(3): 1–23. DOI: 10.1002/jbm.820070303
24. Sauer BW, Weinstein AM, Klawitter JJ, Hulbert SF, Leonard RB, Bagwell JG. The
role of porous polymeric materials in prosthesis attachment. J Biomed Mater Res. 1974; 8(3):
145–53. DOI: 10.1002/jbm.820080315
25. Roderic L. Composite biomaterials. In: Bronzino JD, editor. The biomedical engineering
handbook. Boca Raton, FL: CRC Press; 1995. p. 309–14.
26. Parfitt AM. Osteonal and hemi-osteonal remodeling: the spatial and temporal
framework for signal traffic in adult human bone. J Cell Biochem. 1994 Jul; 55(3): 273–86.
DOI: 10.1002/jcb.240550303
27. Frost HM. Some ABC’s of skeletal pathophysiology. 5. Micro-damage physiology.
Calcif Tissue Int. 1991 Oct;49(4):229-31. DOI: 10.1007/bf02556207
28. P. Pаmies, Long-lived biomaterials, Nat. Biomed. Eng. 1 (2017) 0095. DOI: 10.1038/
s41551-017-0095
29. D. Buser, L. Sennerby, H. De Bruyn, Modern implant dentistry based on osseointegration:
50 years of progress, current trends and open questions. Periodontol 2000. 2017
Feb; 73(1): 7–21. DOI: 10.1111/prd.12185.
30. Harada S, Rodan G. A. Control of osteoblast function and regulation of bone mass.
Nature. 2003 May 15; 423(6937): 349–55. DOI: 10.1038/nature01660
31. le Noble F, le Noble J. Bone biology: Vessels of rejuvenation. Nature. 2014 Mar
20;507(7492):313-4. DOI: 10.1038/nature13210
32. Bose S, Fielding G, Tarafder S, Bandyopadhyay A. Understanding of dopantinduced
osteogenesis and angiogenesis in calcium phosphate ceramics. Trends Biotechnol.
2013 Oct;31(10):594-605.
DOI: 10.1016/j.tibtech.2013.06.005
33. Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the
immune and bone systems. Nat. Nat Rev Immunol. 2007 Apr;7(4):292-304.
DOI: 10.1038/nri2062
34. Vishwakarma А, Bhise NS, Evangelista MB, Rouwkema J, Dokmeci MR, Ghaemmaghami
AM, et al. Engineering immunomodulatory biomaterials to tune the inflammatory
response. Trends Biotechnol. 2016 Jun;34(6):470-482. DOI: 10.1016/j.tibtech.2016.03.009
35. Li Y, Xiao Y, Liu C. The horizon of materiobiology: A perspective on material-Guided
cell behaviors and tissue engineering. Chem Rev. 2017 Mar 8; 117(5): 4376–4421. DOI: 10.1021/
acs.chemrev.6b00654
36. Sul YT. The significance of the surface properties of oxidized titanium to the bone
response: special emphasis on potential biochemical bonding of oxidized titanium implant.
Biomaterials. 2003 Oct; 24(22): 3893–907. DOI: 10.1016/s0142-9612(03)00261-8
37. Hench LL, Polak JM. Third-generation biomedical materials. Science. 2002 Feb 8;
295(5557): 1014–7. DOI: 10.1126/science.1067404
38. Zhao L, Mei S, Chu PK, Zhang Y, Wu Z. The influence of hierarchical hybrid micro/
nano-textured titanium surface with titania nanotubes on osteoblast functions. Biomaterials.
2010 Jul; 31(19): 5072-82. DOI: 10.1016/j.biomaterials.2010.03.014
39. Zhou R, Wei D, Cao J, Feng W, Cheng S, Du Q, et al. Synergistic effects of surface
chemistry and topologic structure from modified microarc oxidation coatings on ti implants for
improving osseointegration. ACS Appl. Mater. Inter. 7 (2015) Apr 8932–8941. DOI: 10.1021/
acsami.5b02226
40. Murphy WL, McDevitt TC, Engler AJ. Materials as stem cell regulators. Nat Mater.
2014 Jun; 13(6): 547–57. DOI: 10.1038/nmat3937
41. Stevens MM, George JH. Exploring and Engineering the Cell Surface Interface.
Science. 2005 Nov 18; 310(5751): 1135–8. DOI: 10.1126/science.1106587
42. Anderson JM, Rodriguez A, Chang DT. Foreign body reaction to biomaterials.
Semin Immunol. 2008 Apr; 20(2): 86–100. DOI: 10.1016/j.smim.2007.11.004
43. Jones JA, Chang DT, Meyerson H, Colton E, Kwon IK, Matsuda T, et al. Proteomic
analysis and quantification of cytokines and chemokines from biomaterial surface-adherent
macrophages and foreign body giant cells. J Biomed Mater Res A. 2007 Dec 1; 83(3): 585–96.
DOI: 10.1002/jbm.a.31221
44. Hench LL, Polak JM. Third-generation biomedical materials. Science. 2002 Feb 8;
295(5557): 1014–7. DOI: 10.1126/science.1067404
45. Jell G, Stevens MM. Gene activation by bioactive glasses. J Mater Sci Mater Med.
2006 Nov; 17(11): 997–1002. DOI: 10.1007/s10856-006-0435-9
46. Kriparamanan R, Aswath P, Zhou A, Tang L, Nguyen KT. Nanotopography: cellular
responses to nanostructured materials. J Nanosci Nanotechnol. 2006 Jul; 6(7):1 905–19.
DOI: 10.1166/jnn.2006.330
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Published
2019-12-16
How to Cite
Міщенко, О. М., Любчак, І. В., Олешко, О. М., & Погорєлов, М. В. (2019). Morphological aspects of the implant-bone interface in the long postoperative periodafter implantation. Actual Dentistry, (5), 75. https://doi.org/10.33295/1992-576X-2019-5-75
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Section
IMPLANTOLOGY
