New dispensary observation protocol of young people (18–25 years old) with periodontal tissue diseases, based on molecular-genetic profile
DOI:
https://doi.org/10.33295/1992-576X-2020-1-12Keywords:
dispensary observation, young age (18–25 years), genetic markers, periodontitis, catarrhal gingivitisAbstract
Background. The high prevalence of periodontal tissue diseases among young people necessitates the search for more informative methods of diagnostic examination.
The purpose of this study is to develop a new dispensary observation protocol based on the identification of the individual molecular-genetic profile of young people (18–25 years old) with and without periodontal tissue diseases using prognostically significant polymorphic variants of ACE, eNOS, and TNF-a genes.
Materials and methods. Under observation for 12 months. there were 40 young people (18–25 years old) with a healthy periodontium, CG and GP, initial-1st. The diagnosis was made based on the classification of periodontal and periimplant diseases and conditions (EFP-AAP, 2017). Molecular-genetic research was based on the isolation of genomic DNA from samples of buccal epithelium.
Results. Analysis of the results of molecular-genetic studies of young people with a healthy periodontium, CG and GP allowed us to form 4 variants of genetic profiles. The dependence of the clinical manifestations of CG, GP on the individual variant of the genetic profile has been established. The possibility of forming a group of persons with a state of pre-disease is shown.
Conclusions. Based on a set of data on the dynamics of periodontal status depending on the genetic profile, a new dispensary observation protocol of young people (18–25 years) has been developed.
Key words: dispensary observation, young age (18–25 years), genetic markers, periodontitis, catarrhal gingivitis.
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