Special aspects of healing wounds after tooth extraction in patients with diabetes mellitus

Abstract

The purpose: of our study was to investigate how the introduction of PRF into a postoperative wound affects the course of its healing after tooth extraction in
patients with diabetes.
Materials and methods. The study involved 20 patients with Type 2 diabetes mellitus, treated in the maxillofacial department of Vinnitsa Regional Pirogov
Clinical Hospital. Histological preparations were immediately prepared from a small part of the fibrinous convolution. The sections of the fibrin convex preparation
were made and stained with fibrin: orange-reddish-blue on Zerbino D.D., Lukasevich L.L. (modified method of Martius-Scarlet-Blue), and also stained with
hematoxylin-eosin.
Results. Histological examination of the fibrin convex colored with hematoxylin-eosin showed that it consists of filaments of fibrin and a large number of platelets.
Conclusions. The use of platelet-rich fibrin (Platelet Rich Fibrin, PRF) after tooth extraction in patients with diabetes mellitus promotes faster regeneration of
the post-extraction well. This can be explained by the fact that thrombocytory growth factors stimulate angiogenesis, and fibrin stimulates proliferation of fibroblasts.
Clinical observations of a mild postoperative period in PRF patients coincided with the OHIP-14 survey data.
Key words: diabetes mellitus, regeneration, Platelet Rich Fibrin, alveolar socket.