Outcomes of autotransplant modifications after secondary alveolar bone grafting in patients with cleft lip and palate

Authors

  • N. V. Kyseliova O. O. Bogomolets National Medical University, Kyiv, Ukraine.
  • V. P. Yefimenko Bogomolets National Medical University, Kyiv, Ukraine.
  • N. A. Tetruyeva National Children’s Specialized Hospital «OKHMATDYT», Kyiv, Ukraine
  • O. I. Holubchenko National Children’s Specialized Hospital «OKHMATDYT», Kyiv, Ukraine

DOI:

https://doi.org/10.33295/1992-576X-2024-2-65

Keywords:

Congenital cleft lip and palate; autograft; bone grafting of the alveolar process; bone bridge height; bone bridge de

Abstract

Purpose. This study aimed to evaluate changes in structural parameters of neoformed osseous tissue after the bone grafting alveolar process with different types of autografts.

Methods. The analysis of the anthropometric indices of neoformed bone tissue was conducted by multispiral computed tomography scanning. 29 children with congenital clefts of the alveolar process aged from 8-17 years were involved in the survey. The autotransplant was used from the mandibular symphysis (I group) and tibia (ІІ group).

Results. The overall success rate of the formed bone bridge in the I group was 66,6% and 57,9% in ІІ group (p = 0,632) according to the Bergland scale of complete regeneration. The average volume of the neoformed osseous tissue constituted in children of the I group stood at 71,0% ± 10,8, in the children of the ІІ group the defect filling appeared to be  68,9% ± 3,7 after 1 year. There was a statistically significant loss of bone volume in percentage equivalent between the I (1%) and II (9,9%) groups over the last 6 months (p = 0,008). During a year the density of the neoformed bone of the I group tended to get 526,1 ± 90,4 HU, in the ІІ group the average density was 288,0 ± 46,3 HU, this is 1,8 times less than in the I group (p = 0,054).

Conclusions. It has been determined that the reparative processes and bone bridge formation of the mandibular  symphysis autotransplant occur more rapidly during the first six months following grafting. At the end of the first year, the bone bridge’s volume and height parameters were similar, but the I group’s density remained higher than that of the II group.

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Author Biographies

N. V. Kyseliova, O. O. Bogomolets National Medical University, Kyiv, Ukraine.

Candidate of Medical Sciences, Associate Professor of the Department of Surgical Dentistry and Pediatric Maxillofacial Surgery of the O. O. Bogomolets National Medical University

V. P. Yefimenko, Bogomolets National Medical University, Kyiv, Ukraine.

Head of the Department of Surgical Dentistry and Maxillofacial Surgery of Children's Age, O. O. Bogomolets National Medical University, Associate Professor, Candidate of Medical Sciences.

N. A. Tetruyeva, National Children’s Specialized Hospital «OKHMATDYT», Kyiv, Ukraine

Doctor of the Department of Plastic and Reconstructive Microsurgery of the National Medical University "Okhmatdyt"

O. I. Holubchenko, National Children’s Specialized Hospital «OKHMATDYT», Kyiv, Ukraine

Doctor of the Department of Plastic and Reconstructive Microsurgery of the National Medical University "Okhmatdyt"

References

Enemark H, Jensen J, Bosch C. Mandibular bone graft material for reconstruction of alveolar cleft defects: long-term results. Cleft palate-craniofacial journal 2001; 38(2):155-63. doi: https://doi.org/10.1597/1545-1569_2001_038_0155_mbgmfr_2.0.co_2 PMid:11294543

Kang NH. Current Methods for the Treatment of Alveolar Cleft. Arch Plast Surg. 2017 May; 44(3):188-193. doi: https://doi.org/10.5999/aps.2017.44.3.188 PMid:28573092 PMCid:PMC5447527

Scalzone A, Flores-Mir C, Carozza D, d'Apuzzo F, Grassia V, Perillo L. Secondary alveolar bone grafting using аutologous versus alloplastic material in the treatment of cleft lip and palate patients: systematic review and meta-analysis. Progress in Orthodontics 2019; 11;20(1):6. doi: https://doi.org/10.1186/s40510-018-0252-y PMid:30740615 PMCid:PMC6369233

Wahaj A, Hafeez K, Zafar MS. Role of bone graft materials for cleft lip and palate patients: A systematic review. The Saudi Journal for Dental Research 2016; 7: 57-63. doi: https://doi.org/10.1016/j.sjdr.2015.02.001

Wu C, Pan W, Feng C, Su Z, Duan Z, Zheng Q, et al. Grafting materials for alveolar cleft reconstruction: a systematic review and best-evidence synthesis. Int. J. Oral Maxillofac. Surg. 2017; 12p. http://dx.doi.org/10.1016/j.ijom.2017.08.003. https://doi.org/10.1016/j.ijom.2017.08.003 PMid:28863859

Stasiak M, Wojtaszek-Słomińska A, Racka-Pilszak B. A novel method for alveolar bone grafting assessment in cleft lip and palate patients: cone-beam computed tomography evaluation. Clin Oral Investig. 2021 Apr;25(4):1967-1975. doi: https://doi.org/10.1007/s00784-020-03505-z PMid:32803441 PMCid:PMC7966225

Attar BM, Soltani P, Davari D, Mehdizadeh M. Cone-beam computed tomographic comparison of chin symphysis bone particles and allograft versus iliac crest bone graft alone for reconstruction of alveolar bone defects in cleft patients. J Korean Assoc Oral Maxillofac Surg. 2022 Apr 30;48(2):85-93. doi: https://doi.org/10.5125/jkaoms.2022.48.2.85 PMid:35491139 PMCid:PMC9065643

Leal CR, de Carvalho RM, Ozawa TO, de Almeida AM, Dalben GS, et al. Outcomes of alveolar graft with rhbmp-2 in clp: influence of cleft type and width, canine eruption, and surgeon. Cleft Palate Craniofac J 2019; 56(3):383-389. doi: https://doi.org/10.1177/1055665618780981 PMid:29924638

Park Y-W, Lee J-H. Use of mandibular chin bone for alveolar bone grafting in cleft patients. Maxillofac Plast Reconstr Surg. 2016; 38(1): 45. doi: https://doi.org/10.1186/s40902-016-0091-z PMid:27995118 PMCid:PMC5122602

Fukuta K, Kurita K, Goto M. Invasiveness of tibial bone graft harvesting for secondary alveolar bone grafting: can harvesting be performed at the age of less than 10 years without complications? American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 2017; 75:2628-2637. doi: https://doi.org/10.1016/j.joms.2017.06.024 PMid:28732218

Atil F, Kocyigit ID, Suer BT, Alp YE, Yazan M, Tekin U. Clinical evaluation of the use of tibial bone grafting in dentoalveolar reconstructive surgery. Med Princ Pract 2016; 25:72-78. https://doi.org/10.1159/000440998. PMid:26501218 PMCid:PMC5588298

Khalil W, de Musis CR, Volpato LER, Veiga K A, Vieira EMM, Aranha AM . Clinical and radiographic assessment of secondary bone graft outcomes in cleft lip and palate patients. International Scholarly Research Notices. 2014; 10:8 p. https://doi.org/10.1155/2014/231795 PMid:27351004 PMCid:PMC4897589

Vura N, Gaddipati R, Ramisetty S, Thumu SK, Bhukya L. The Use of Tibial Autogenous Cancellous Bone for Late Secondary Alveolar Bone Grafting in Cleft Patients: A Prospective Study. J Maxillofac Oral Surg. 2021 Jun;20(2):276-281. doi: https://doi.org/10.1007/s12663-020-01350-x PMid:33927498 PMCid:PMC8041926

Yu X, Huang Y, Li W. Correlation between alveolar cleft morphology and the outcome of secondary alveolar bone grafting for unilateral cleft lip and palate. BMC Oral Health. 2022 Jun 22;22(1):251. doi: https://doi.org/10.1186/s12903-022-02265-4 PMid:35733126 PMCid:PMC9219156

Miyagawa K, Tanaka S, Hiroishi S, Matsushita Y, Murakami S, Kogo M. Comparative evaluation of bone microstructure in alveolar cleft repair by cone beam CT: influence of different autologous donor sites and additional application of β-tricalcium phosphate. Clin Oral Investig. 2020; 24(8):2789-2797. doi: https://doi.org/10.1007/s00784-019-03142-1 PMid:31707628

Published

2024-04-29

How to Cite

Kyseliova . Н. В., Yefimenko В. П., Tetruyeva Н. А., & Holubchenko . О. І. (2024). Outcomes of autotransplant modifications after secondary alveolar bone grafting in patients with cleft lip and palate. Actual Dentistry, (2), 65–69. https://doi.org/10.33295/1992-576X-2024-2-65

Issue

Section

MAXILLOFACIAL SURGERY AND SURGICAL DENTISTRY