Mechanistically Guided Development of a Bioactive Chitosan/Magnesium-Doped Hydroxyapatite Nanocomposite Scaffold for Osteogenic and Antibacterial Bone Regeneration

Proposed Research Based on the Preliminary Findings of an Electrospun CS/Mg-HAp Scaffold Co-Loaded with Icariin, Lithium Chloride and Naringin

Authors

  • Sahar Hefzollesan Medera Hospital, Baku, Azerbaijan
  • Rizvan Mammadov Azerbaijan Medical University, Baku, Azerbaijan

DOI:

https://doi.org/10.33295/1992-576X-2026-4-EDEN-1

Keywords:

Bone tissue engineering, nanocomposite scaffold, chitosan, magnesium-doped hydroxyapatite, electrospinning, icariin, lithium chloride, naringin, Wnt/β-catenin signaling, osteogenesis, antibacterial activity, 3D biomaterials, bone regeneration

Abstract

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Author Biographies

Sahar Hefzollesan, Medera Hospital, Baku, Azerbaijan

Head of Dental Department
ORCID: https://orcid.org/0009-0007-2728-8154

Rizvan Mammadov, Azerbaijan Medical University, Baku, Azerbaijan

Department of Therapeutic Dentistry
ORCID: https://orcid.org/0009-0004-4765-9248

References

Vallet-Regí, M., Salinas, A. J., & Cordero, D. (2026). From bone replacement to regeneration: A biomaterials started journey. Materials Today Bio, 15, 100250. DOI: https://doi.org/10.1016/j.mtbio.2026.103282

Kostadinova, M., Petrov, P., & Ivanov, I. (2025). Recent advances in bone tissue engineering: Enhancing the potential of mesenchymal stem cells for regenerative therapies. Current Issues in Molecular Biology, 47(2), 1120–1145. DOI: https://doi.org/10.3390/cimb47040287

Qi, L., Zhang, Y., & Liu, X. (2024). Advances in magnesium-containing bioceramics for bone repair. Biomaterials Translational, 5(3), 201–215.

Babu, S., Kumar, A., & Chen, Q. (2026). Magnesium-based composite scaffolds for therapeutic delivery in bone tissue engineering: Current advances and emerging frontiers. Journal of Magnesium and Alloys, 14(1), 45–68. DOI: https://doi.org/10.1016/j.jma.2026.102029

Shanmugavadivu, A., Selvakumar, R., & Ramasamy, S. (2025). Surface engineering of 3D-printed polylactic acid scaffolds with polydopamine and 4-methoxycinnamic acid–chitosan nanoparticles for bone regeneration. Nanoscale Advances, 7(4), 980–992. DOI: https://doi.org/10.1039/D4NA00768A

Di Stefano, A., Rossi, M., & Lombardi, G. (2025). Effect of nanocomposite chitosan/hydroxyapatite pH-induced hydrogels on the osteogenic differentiation of spheroids from adipose stem cells. International Journal of Biological Macromolecules, 280, 135420. DOI: https://doi.org/10.1016/j.ijbiomac.2025.140213

Zhang, L., Yang, G., Johnson, B. N., & Jia, X. (2019). Three-dimensional (3D) printed scaffold and material selection for bone repair. Acta Biomaterialia, 84, 16–33. DOI: https://doi.org/10.1016/j.actbio.2018.11.039

Frumento, D., Ali, M., & Mastrangelo, F. (2025). Immunomodulatory potential and biocompatibility of chitosan–hydroxyapatite biocomposites for tissue engineering. Journal of Composites Science, 9(2), 75. DOI: https://doi.org/10.3390/jcs9060305

Ait Said, H., Ben-Zineb, K., & Lachkar, M. (2023). Manufacturing methods, properties, and potential applications in bone tissue regeneration of hydroxyapatite-chitosan biocomposites: A review. International Journal of Biological Macromolecules, 243, 125150. DOI: https://doi.org/10.1016/j.ijbiomac.2023.125150

Safitri, N., Wibowo, A., & Kusumastuti, R. (2026). Hydroxyapatite-chitosan biocomposites: Fabrication strategies and biological performance in bone regeneration. International Journal of Biological Macromolecules, 366, 152422. DOI: https://doi.org/10.1016/j.ijbiomac.2026.152422

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Published

2026-09-15

How to Cite

Hefzollesan, S., & Mammadov, R. (2026). Mechanistically Guided Development of a Bioactive Chitosan/Magnesium-Doped Hydroxyapatite Nanocomposite Scaffold for Osteogenic and Antibacterial Bone Regeneration: Proposed Research Based on the Preliminary Findings of an Electrospun CS/Mg-HAp Scaffold Co-Loaded with Icariin, Lithium Chloride and Naringin. Actual Dentistry, (4). https://doi.org/10.33295/1992-576X-2026-4-EDEN-1

Issue

Section

EXPERIMENTAL DENTISTRY