ПАРОДОНТОЛОГИЯ
Выводы.
Результаты микробиологических исследований свидетельствуют о выраженной антибактериальной активности всех образцов силикагеля с нано-
частицами металлов относительно референтных тестовых штаммов микроорганизмов, а также микробной флоры пародонтальных карманов больных гене-
рализованным пародонтитом.
Ключевые слова:
силикагели с наночастицами металлов, антибактериальное действие.
Microbiological background of the inflammatory periodontal diseases treating
with gold and silver nanoparticles
O. Tkach, O. Voloshchuk
Actuality.
A significant number of antibacterial and anti-inflammatory drugs are used for the treatment of periodontal diseases. However, the potentialities of many
drugs, especially antibiotics, are severely limited due to the rapid addiction and loss of sensitivity of periodontopathogenic microflora to them. Therefore, the devel-
opment of new antibiotics to which sensitivity of periodontopathogenic microflora will be preserved for a longer time is an actual problem.
Aim:
to determine the antibacterial properties of silver and gold nanoparticles concerning pathogenic microorganisms isolated from periodontal pockets of patients
with generalized periodontitis.
Materials and methods.
The study used highly dispersed silicagels containing on its surface nanoparticles of silver and gold, reference test strains and mixed
microflora of periodontal pockets of patients with generalized periodontitis. The method of agar diffusion was used to determine the antibacterial action of silicagels’
samples.
Results.
Study of in vitro antimicrobial properties of silicagels containing nanoparticles of gold and silver regarding test strains has showed various levels of anti-
bacterial activity.
Determination of the antibacterial action of the compounds regarding mixed microflora isolated from periodontal pockets of patients with generalized periodontitis has
showed a presence of a pronounced antibacterial activity of silicagels’ samples.
Conclusions.
The results of microbiological studies show a severe antibacterial activity of silicagels’ samples with nanoparticles of metals relative to the reference
test of microorganisms and microbial flora of periodontal pockets of patients with generalized periodontitis.
Key words:
silicagels with metals nanoparticles, antibacterial activity.
Ткач Оксана Борисівна
– асистент кафедри стоматології
інституту післядипломної освіти Національного медичного університету імені О.О. Богомольця.
Тел.:
(050) 542-95-47, (098) 080-96-20.
E-mail:
.
О.М. Волощук
– Національний медичний університет імені О.О. Богомольця, м. Київ, Україна.
